A randomized double-blinded study assessing the effect of different doses of transnasal dexmedetomidine on the median effective concentration of ropivacaine for a caudal block.

ABSTRACT:

Background

Perineural administration of dexmedetomidine (PN-DEX) can enhance the efficacy of local anesthetics used in regional nerve blocks while decreasing the median effective concentration (EC50) of these anesthetics. Intranasal administration of dexmedetomidine (IN-DEX) is more accessible for sedation during regional anesthesia because of its non-invasive systemic administration and demonstrates synergism with local anesthetic. However, it remains unclear whether IN-DEX affects the EC50 of local anesthetics used in caudal blocks.

Methods

This study was a prospective, single-center, double-blind, randomized controlled trial. Patients scheduled to undergo elective hemorrhoidectomy were included and divided into three groups. Furthermore, 0.01 mL/kg of normal saline and 1 

SUBMITTER: Wang F 

PROVIDER: S-EPMC11608987 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature