Gestational organophosphate esters (OPEs) and executive function in adolescence: The HOME Study.

ABSTRACT:

Background

Evidence from toxicological studies indicate organophosphate esters (OPEs) are neurotoxic, but few epidemiological studies investigated associations between gestational OPEs and executive function.

Objective

To examine the associations between gestational concentrations of OPE urinary metabolites and executive function at 12 years.

Methods

We used data from 223 mother-adolescent dyads from the Health Outcomes of Measures of the Environment (HOME) Study. Women provided spot urine samples at 16 weeks gestation, 26 weeks gestation, and at delivery for quantification of bis(1,3-dichloro-2-propyl) phosphate, bis-2-chloroethyl phosphate (BCEP), diphenyl phosphate (DPHP), and di-n-butyl phosphate (DNBP). Executive function was assessed at age 12 years using the pa

SUBMITTER: Vuong AM 

PROVIDER: S-EPMC11609008 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature