Transmissible long-term neuroprotective and pro-cognitive effects of 1-42 beta-amyloid with A2T icelandic mutation in an Alzheimer's disease mouse model.

ABSTRACT: The amyloid cascade hypothesis assumes that the development of Alzheimer's disease (AD) is driven by a self-perpetuating cycle, in which β-amyloid (Aβ) accumulation leads to Tau pathology and neuronal damages. A particular mutation (A673T) of the amyloid precursor protein (APP) was identified among Icelandic population. It provides a protective effect against Alzheimer- and age-related cognitive decline. This APP mutation leads to the reduced production of Aβ with A2T (position in peptide sequence) change (Aβ_ice). In addition, Aβ_ice has the capacity to form protective heterodimers in association with wild-type Aβ. Despite the emerging interest in Aβ_ice during the last decade, the impact of Aβ_ice on events associated with the amyloid cascade has n

SUBMITTER: Celestine M 

PROVIDER: S-EPMC11609088 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature