GluK1 kainate receptors are necessary for functional maturation of parvalbumin interneurons regulating amygdala circuit function.

ABSTRACT: Parvalbumin expressing interneurons (PV INs) are key players in the local inhibitory circuits and their developmental maturation coincides with the onset of adult-type network dynamics in the brain. Glutamatergic signaling regulates emergence of the unique PV IN phenotype, yet the receptor mechanisms involved are not fully understood. Here we show that GluK1 subunit containing kainate receptors (KARs) are necessary for development and maintenance of the neurochemical and functional properties of PV INs in the lateral and basal amygdala (BLA). Ablation of GluK1 expression specifically from PV INs resulted in low parvalbumin expression and loss of characteristic high firing rate throughout development. In addition, we observed reduced spontaneous excitatory synaptic activity at adult GluK1 l

SUBMITTER: Haikonen J 

PROVIDER: S-EPMC11609095 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature