Placebo effects in randomized trials of pharmacological and neurostimulation interventions for mental disorders: An umbrella review.

ABSTRACT: There is a growing literature exploring the placebo response within specific mental disorders, but no overarching quantitative synthesis of this research has analyzed evidence across mental disorders. We carried out an umbrella review of meta-analyses of randomized controlled trials (RCTs) of biological treatments (pharmacotherapy or neurostimulation) for mental disorders. We explored whether placebo effect size differs across distinct disorders, and the correlates of increased placebo effects. Based on a pre-registered protocol, we searched Medline, PsycInfo, EMBASE, and Web of Knowledge up to 23.10.2022 for systematic reviews and/or meta-analyses reporting placebo effect sizes in psychopharmacological or neurostimulation RCTs. Twenty meta-analyses, summarising 1,691 RCTs involving 261,73

SUBMITTER: Huneke NTM 

PROVIDER: S-EPMC11609099 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature