Modulation of local immunity by the vaginal microbiome is associated with triggering spontaneous preterm birth.

ABSTRACT:

Objective

This study aimed to identify immune states associated with a high risk of preterm birth by immunophenotyping in pregnant populations, and to elucidate the characteristics of immune subtypes and their relationships with preterm birth. Additionally, it sought to uncover the microbial composition and functional characteristics of immune states linked to preterm birth, and to evaluate the impact of bacterial interactions on the initiation of preterm birth.

Methods

Utilizing 16S rRNA sequencing data and local immune factor expression data from a publicly available longitudinal pregnancy cohort, we conducted immunophenotyping through unsupervised clustering of the immune factors. We compared the differences in vaginal microbiota richness, diversity, and composition betwe

SUBMITTER: Liang Y 

PROVIDER: S-EPMC11609181 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature