Level of involvement of four selected cytochrome P450s (CYPs) in pyrethroid-resistant <i>Anopheles gambiae</i> (<i>s.s.</i>) and <i>Anopheles coluzzii</i> across Cote d'Ivoire.

ABSTRACT: In Côte d'Ivoire, there is a high intensity of pyrethroid resistance in malaria vectors which may threaten successful vector control. Molecular studies of the target site mutation in the voltage-gated sodium channel (VGSC) 1014F show that the gene frequencies of these mutations are high, widely spread across Côte d'Ivoire, and even fixed in some areas. To further characterize insecticide resistance in Côte d'Ivoire beyond target site mutations, the metabolic resistance mechanism was explored. Overexpression of the metabolic enzyme cytochrome CYP6M2, CYP6P3, CYP6P4, and CYP6P5 was investigated in Anopheles gambiae (s.s.) and An. coluzzii collected from 30 insecticide resistance monitoring sites across the country in 2021 and 2022. Quan

SUBMITTER: Chabi J 

PROVIDER: S-EPMC11609257 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature