Socioeconomic disadvantage and polygenic risk of overweight in early and mid-life: a longitudinal population cohort study spanning 12 years.

ABSTRACT:

Background

We describe BMI by socioeconomic disadvantage and by polygenic risk in parallel cohorts of children and adults (their parents). We examine whether hypothetically intervening to reduce childhood disadvantage could reduce adolescent obesity.

Methods

From a population-based cohort (N = 5107) with a mixed design (survey and direct assessment), 24-31% had genotype data: 1607 children (50% male) followed biennially from age 2-3 to 14-15; 2406 adults (36% male) followed from mean age 35-47 years. Exposures were polygenic risk score for BMI, and neighbourhood- and family-level socioeconomic disadvantage categorised as 'most' (top two cohort-specific quintiles), 'average', or 'least' disadvantage (bottom two quintiles). We explored trends in estimated BMI and risk of overw

SUBMITTER: Kerr JA 

PROVIDER: S-EPMC11609315 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature