Disentangling the unique contributions of age, pubertal stage, and pubertal hormones to brain structure in childhood and adolescence.

ABSTRACT: Puberty and associated changes in pubertal hormones influence structural brain development. Hormones such as dehydroepiandrosterone (DHEA) and progesterone remain understudied, and it remains unclear how these aspects of puberty contribute uniquely to structural brain development. We used the Human Connectome Project in Development cross-sectional sample of 1304 youth (aged 5-21 years) to investigate unique contributions of sex, age, pubertal stage, DHEA, testosterone, estradiol, and progesterone to cortical thickness, surface area, and subcortical volume development within functionally-relevant networks. Sex and age explain the most unique variance in all three aspects of structural development. Pubertal stage and pubertal hormones uniquely contribute more to cortical surface area, compar

SUBMITTER: Curtis M 

PROVIDER: S-EPMC11609316 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature