Platelet Ido1 expression is induced during Plasmodium yoelii infection, altering plasma tryptophan metabolites.

ABSTRACT:

Abstract

Platelets are immune responsive in many diseases as noted by changes in platelet messenger RNA in conditions such as sepsis, atherosclerosis, COVID-19, and many other inflammatory and infectious etiologies. The malaria causing Plasmodium parasite is a persistent public health threat and significant evidence shows that platelets participate in host responses to infection. Using a mouse model of nonlethal/uncomplicated malaria, non-lethal Plasmodium yoelii strain XNL (PyNL)-infected but not control mouse platelets expressed Ido1, a rate limiting enzyme in tryptophan metabolism that increases kynurenine at the expense of serotonin. Interferon-γ (IFN-γ) is a potent inducer of Ido1 and mice treated with recombinant IFN-γ had increased platelet Ido1 and IDO1 activity. PyNL-infec

SUBMITTER: Blick-Nitko SK 

PROVIDER: S-EPMC11609358 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature