Intraindividual Variability of Event-Related Potentials in Psychosis: A Registered Report.

ABSTRACT:

Background

Neurophysiological tools have yielded valuable insights into the pathophysiology and treatment of psychosis. However, studies using event-related potentials (ERPs) have primarily focused on mean scores and neglected the within-person variability of ERP scores. The neglect of within-person variability of ERPs in the search for biomarkers might have resulted in crucial differences related to psychosis being missed. In this registered report, we aimed to determine whether distinct patterns of intraindividual variability in ERP biomarkers would be observed in people with a lifetime psychosis diagnosis.

Methods

Publicly available data posted to the National Institute of Mental Health Data Archive for 1R01MH110434-01 was obtained for 162 patients with a lifetime history

SUBMITTER: Holbrook A 

PROVIDER: S-EPMC11609361 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature