Fecal deoxycholic acid associates with diet, intestinal microbes, and total bilirubin in primary sclerosing cholangitis.

ABSTRACT:

Background & aims

Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease with a strong association with inflammatory bowel disease and variable disease progression. We aimed to gain insights into the role of fecal bile acids (BA) on disease progression by determining the relationships between fecal BA, diet, and gut microbes, with markers of disease progression, BA synthesis, and farnesoid X receptor (FXR) activity.

Methods

BA levels in serum and stool, dietary intake, and markers of BA synthesis, and FXR activity were measured in 26 patients with early stage, large duct PSC. Fecal microbiota were quantified by 16S rRNA gene sequencing.

Results

Compared with controls, fecal unconjugated deoxycholic acid (DCA) levels were lower in patients with PSC

SUBMITTER: Chan C 

PROVIDER: S-EPMC11609371 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature