A portable and sensitive DNA-based electrochemical sensor for detecting piconewton-scale cellular forces.

ABSTRACT:

Background

Cell-generated forces are a key player in cell biology, especially during cellular shape formation, migration, cancer development, and immune response. The measurement of forces exerted and experienced by cells is fundamental in understanding these mechanosensitive cellular behaviors. While cell-generated forces can now be detected based on techniques like fluorescence microscopy, atomic force microscopy, optical/magnetic tweezers, however, most of these approaches rely on complicated instruments or materials, as well as skilled operators, which could limit their potential broad applications in regular biological laboratories.

Results

A new type of smartphone-based electrochemical sensor is developed here for cellular force measurement. In this system, a double-st

SUBMITTER: Amouzadeh Tabrizi M 

PROVIDER: S-EPMC11609405 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature