Is there an association between colonisation of vancomycin resistant <i>Enterococci</i>, methicillin resistant <i>Staphylococcus Aureus</i>, or <i>Clostridiodes Difficile</i> and mortality in sepsis?

ABSTRACT:

Background

To determine if colonisation with drug resistant organisms is associated with worse outcomes in patients who subsequently develop sepsis.

Methods

Retrospective study of patients with sepsis employing logistic regression and linear regression to determine the independent association of colonisation with adverse outcomes.

Results

Mortality was higher in patients colonized with VRE [501 of 1937 (26%) v. 1052 of 5624 (19%) non-VRE colonised patients, difference 7% (95% confidence interval (5,9%), p<0.001] and MRSA [168 of 708 (24%) v 1342 of 6804 (20%) non-MRSA colonised patients, difference 4% (1,7%), p = 0.014]. CDiff colonisation was not associated with increased mortality [153 of 757 (21%) v 762 of 7432 (18%), difference 3% (0,6%), p=0.052]. After multivari

SUBMITTER: Sigakis MJ 

PROVIDER: S-EPMC11609449 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature