Bi-modal confirmation of liposome delivery to the brain after focused ultrasound-induced blood-brain barrier opening.

ABSTRACT: Focused ultrasound-mediated opening of the blood-brain barrier offers a great opportunity to deliver therapeutics into hard-to-treat brain tumors such as glioblastoma multiforme or diffuse midline glioma. However, the potential of the technique to offer a time window for efficient nanomedicine delivery has not been thoroughly studied. Non-invasive and targeted delivery of large drug-loaded nanocarriers, such as liposomes, could offer a safe and scalable method of personalized therapy for the treatment of brain pathologies. Additionally, it is essential to monitor the safety and efficacy of such treatments, tracking drug delivery in real-time through quantitative medical imaging. In this study, liposomes were modified to have an MRI contrast agent (i.e., Gd) in both lipid membrane and core,

SUBMITTER: Payne C 

PROVIDER: S-EPMC11609457 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature