Metabolomic profiles differentiate between porto-sinusoidal vascular disorder, cirrhosis, and healthy individuals.

ABSTRACT:

Background & aims

Porto-sinusoidal vascular disorder (PSVD) is a rare and diagnostically challenging vascular liver disease. This study aimed to identify distinct metabolomic signatures in patients with PSVD or cirrhosis to facilitate non-invasive diagnosis and elucidate perturbed metabolic pathways.

Methods

Serum samples from 20 healthy volunteers (HVs), 20 patients with histologically confirmed PSVD or 20 patients with cirrhosis were analyzed. Metabolites were measured using liquid chromatography-mass spectrometry. Differential abundance was evaluated with Limma's moderated t-statistics. Artificial neural network and support vector machine models were developed to classify PSVD against cirrhosis or HV metabolomic profiles. An independent cohort was used for validation.

SUBMITTER: Semmler G 

PROVIDER: S-EPMC11609546 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature