Interplay between Lipids and Complement Proteins-How Multiomics Data Integration Can Help Unravel Age-related Macular Degeneration Pathophysiology: A Proof-of-concept Study.

ABSTRACT:

Objective

Our objectives were to identify correlation patterns between complement and lipid pathways using a multiomics data integration approach and to determine how these interconnections affect age-related macular degeneration (AMD).

Design

Nested case-control study.

Subjects and controls

The analyses were performed in a subset of the Singapore Indian Eye Study. We randomly selected 155 AMD cases and age- and sex-matched them with 155 controls.

Methods

Firstly, a multiomics data integration method was used to identify correlation patterns between the omics data. Then, we tested possible interactions between the lipids and complement proteins using logistic regression models.

Main outcome measures

Age-related macular degeneration was determined accordi

SUBMITTER: Nusinovici S 

PROVIDER: S-EPMC11609548 | biostudies-literature | 2025 Jan-Feb

REPOSITORIES: biostudies-literature