The separation between mRNA-ends is more variable than expected.

ABSTRACT: Effective circularization of mRNA molecules is a key step for the efficient initiation of translation. Research has shown that the intrinsic separation of the ends of mRNA molecules is rather small, suggesting that intramolecular arrangements could provide this effective circularization. Considering that the innate proximity of RNA ends might have important unknown biological implications, we aimed to determine whether the close proximity of the ends of mRNA molecules is a conserved feature across organisms and gain further insights into the functional effects of the proximity of RNA ends. To do so, we studied the secondary structure of 274 full native mRNA molecules from 17 different organisms to calculate the contour length (C_L) of the external loop as an index of their end-to

SUBMITTER: Gerling N 

PROVIDER: S-EPMC11609591 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature