Comprehensive pan-cancer analysis of CD73: Explore its association with prognosis and tumor immune microenvironment.

ABSTRACT:

Background

CD73 is adenosine generation molecule, which is involved in the immune regulation. However, the roles of CD73 in the tumor microenvironment remain unknown.

Methods

CD73 expression levels in pan-cancers were analyzed, based on The Cancer Genome Atlas (TCGA), Genotype-Tissue Expression (GTEx) and Human Protein ALTAS (HPA) databases. Kaplan-Meier (KM) plotter was used to analyze the prognostic values of CD73. Immune scores in pan-cancers was evaluated by ESTIMATE. TIMER2.0 and UCSCXena were used to explore the correlation between CD73 and immune infiltration/immune checkpoints/tumor mutation burden (TMB)/microsatellite instability (MSI). CD73 expression correlated genes in tumor tissues were screened by using LinkedOmics tool.

Results

Firstly, CD73 was signifi

SUBMITTER: Chen C 

PROVIDER: S-EPMC11609644 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature