Rare Non-Cryptic <i>NUP98</i> Rearrangements Associated With Myeloid Neoplasms and Their Poor Prognostic Impact.

ABSTRACT:

Background

NUP98 rearrangements (NUP98r), associated with various hematologic malignancies, involve more than 30 partner genes. Despite their clinical significance, reports on the clinicopathological characteristics of rare NUP98r remain limited. We investigated the characteristics of patients with myeloid neoplasms harboring NUP98r among those identified as having 11p15 translocation in chromosomal analysis.

Methods

We retrospectively reviewed results from bone marrow chromosomal analyses conducted between 2011 and 2023 and identified 15 patients with 11p15 translocation. Subsequently, NUP98r were evaluated using FISH and/or reverse transcription PCR, and clinical and laboratory data of the patients were analyzed.

Results

NUP98</

SUBMITTER: Park MS 

PROVIDER: S-EPMC11609711 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature