Biological aging analysis based on DNA methylation status for social anxiety disorder.

ABSTRACT:

Aim

Social anxiety disorder (SAD) is a common disorder characterized by excessive fear of scrutiny and embarrassment, leading to severe distress and avoidance behaviors or dysfunctions. SAD and other relevant diseases have been reported to be associated with a higher risk of aging-related diseases, such as Alzheimer's disease, Parkinson's disease, and diabetes mellitus. Recently, epigenetic clock analysis, which measures biological aging based on comprehensive DNA methylation (DNAm) status, has been widely conducted. We conducted epigenetic clock analyses in patients with SAD and controls, examining various epigenetic age acceleration and DNAm-based predictive values of aging-related proteins (GrimAge components and GrimAge2 components), including leptin level.

Methods

We us

SUBMITTER: Noguchi N 

PROVIDER: S-EPMC11609738 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature