TREM2-Expressing Multinucleated Giant Macrophages Are a Biomarker of Good Prognosis in Head and Neck Squamous Cell Carcinoma.

ABSTRACT:

Significance

Novel individual biomarkers are needed to guide therapeutic decisions for patients with head and neck cancer. We report for the first time, granulomas of TREM2-expressing multinucleated giant macrophages in keratin-rich tumor niches, as a biomarker of favorable prognosis and developed a deep-learning model to automate its quantification on routinely stained pathological slides.

SUBMITTER: Gessain G 

PROVIDER: S-EPMC11609822 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature