The 330 risk loci known for systemic lupus erythematosus (SLE): a review.

ABSTRACT: An in-depth literature review of up to 2023 reveals 330 risk loci found by genetic association at p ≤ 5 × 10^-8, with systemic lupus erythematosus (SLE) in at least one study of 160 pertinent publications. There are 225 loci found in East Asian (EAS), 106 in European (EU), 11 in African-American (AA), 18 Mixed American (MA), and 1 in Egyptian ancestries. Unexpectedly, most of these associations are found to date at p ≤ 5 × 10^-8 in a single ancestry. However, the EAS and EU share 40 risk loci that are independently established. The great majority of the identified loci [250 (75.8%) of 330] do not contain a variant that changes an amino acid sequence. Meanwhile, most overlap with known regulatory elements in the genome [266 (80.6%) of 330], suggesting a maj

SUBMITTER: Laurynenka V 

PROVIDER: S-EPMC11609870 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature