Adverse childhood experiences, brain efficiency, and the development of pain symptoms in youth.

ABSTRACT:

Background

Adverse childhood experiences (ACEs) are often reported by youths with chronic pain, and both ACEs and chronic pain disrupt how information is processed. However, it is unknown whether changes to shared neural networks underlie the relationship between ACEs and the development of pain symptoms. This study explored the relationships between ACEs, brain efficiency, and pain symptomology in youth.

Methods

A community sample of youths aged 14-18 years underwent MRIs, answered trauma and pain questionnaires, and underwent pain sensory testing, twice, 3 months apart (N_baseline = 44; N_follow-up = 42). Sensory testing determined thresholds for mechanical and thermal stimuli. Global and local network efficiencies were evaluated using graph theory. Gen

SUBMITTER: Miller S 

PROVIDER: S-EPMC11609899 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature