Development of Broad-Spectrum β-Cyclodextrins-Based Nanomaterials Against Influenza Viruses.

ABSTRACT: In recent decades, epidemics and pandemics have multiplied throughout the world, with viruses generally being the primary responsible agents. Among these, influenza viruses play a key role, as they potentially cause severe respiratory distress, representing a major threat to public health. Our study aims to develop new broad-spectrum antivirals against influenza to improve the response to viral disease outbreaks. We engineered macromolecules (named CD-SA) consisting of a β-cyclodextrin scaffold modified with hydrophobic linkers in the primary face, onto which unitary sialic acid epitopes are covalently grafted to mimic influenza virus-host receptors. We assessed the antiviral efficacy, mechanism of action, and the genetic barrier to resistance of this compound against influenza in vitro, e

SUBMITTER: Zwygart AC 

PROVIDER: S-EPMC11609907 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature