Suggestive evidence of male specific genetic association of IL8 -251T>A promoter polymorphism with primary angle closure glaucoma in a north Indian Punjabi population.

ABSTRACT:

Background

Overproduction of IL-8 in the retina and optic nerve may affect the survival of retinal ganglion cells (RGCs) and contribute to axonal damage in glaucoma. The -251T > A functional variant in the promoter region of the IL8 gene is known to affect its transcriptional activity, as demonstrated in in vitro assays.

Methods

The present study investigates the genetic association of this polymorphism with primary glaucoma in a North Indian Punjabi cohort. A total of 226 primary open angle glaucoma (POAG), 132 primary angle closure glaucoma (PACG) patients and 424 matched controls were recruited. Genotyping was performed using the restriction length polymorphism (RFLP) method.

Results

Association analysis was done by PLINK software and appropriate corrections were a

SUBMITTER: Thakur N 

PROVIDER: S-EPMC11610091 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature