Cardiovascular autonomic neuropathy in chronic kidney disease: a study of kidney biopsy cases.

ABSTRACT:

Background

The interplay between cardiac and kidney functions is mediated by the autonomic nervous system. Cardiovascular autonomic neuropathy (CAN) is a well-documented dysfunction of this system, with heart rate variability (HRV) serving as the principal diagnostic tool. CAN is recognized as a prognostic marker for adverse kidney outcomes in diabetic kidney disease (DKD). However, the pathogenesis of CAN in patients with nondiabetic chronic kidney disease (CKD) remains underexplored. This study elucidated the prevalence of CAN and its clinicopathologic characteristics in patients with nondiabetic CKD.

Methods

This cross-sectional analysis evaluated 165 nondiabetic CKD patients who underwent kidney biopsy from 2020 to 2023. HRV was quantified using the coefficient of variat

SUBMITTER: Kuno H 

PROVIDER: S-EPMC11610099 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature