The associations of candidate gene polymorphisms with aspirin resistance in patients with ischemic disease: a meta-analysis.

ABSTRACT:

Background

Recently, extensive research has been conducted on the relationship between aspirin gene polymorphisms and aspirin resistance (AR) in patients with ischemic diseases. Among the numerous candidate genes, it remains unclear which ones are significantly associated with AR and could potentially serve as potential biomarkers for genetic testing before aspirin use.

Methods

Eligible articles were searched in PubMed, Embase, Cochrane Library, WanFang, CNKI and Sinomed. A cohort study examining the efficacy of aspirin in secondary prevention for patients with ischemic diseases, along with a discussion on genetic polymorphisms and their association with AR, has been included. The Newcastle-Ottawa Scale for assessing the quality of included studies. Odds ratios (OR) with 95%

SUBMITTER: Li CX 

PROVIDER: S-EPMC11610159 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature