IONIC NANOMEDICINE STRATEGY TO DEVELOP EFFECTIVE CHEMO-PTT COMBINATION CANCER THERAPEUTICS.

ABSTRACT: Herein, a detailed investigation of nanodrugs derived by combining a chemotherapy (chemo) and photothermal therapy (PTT) approaches to enhance chemo drug efficacy is presented. Tamoxifen and its metabolite; N-desmethyltamoxifen are the selected chemo drugs that were electrostatically attached with a PTT agent, NaIR820, via a metathesis approach to develop two different ionic material (IM)-based chemo-PTT drugs. Ionic nanomaterials (INMs) were synthesized using reprecipitation method, and these carrier- free nanoparticles were characterized in detail. Photophysical properties of NaIR820 parent compound, and their derived chemo-PTT IMs and INMs revealed significant alterations in absorption and fluorescence emission spectra of IR820. Photophysical results demonstrated that INMs exhibited pro

SUBMITTER: Bashiru M 

PROVIDER: S-EPMC11610177 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature