Sexual dimorphism in the effects of maternal adipose tissue growth hormone receptor deficiency on offspring metabolic health.

ABSTRACT:

Background

The global incidence of obesity continues to rise, which increases the prevalence of metabolic diseases. We previously demonstrated the beneficial effect of adipose-specific growth hormone receptor (Ghr) knockout (KO) on metabolic parameters in male mice exposed to high fat diet. Although the effect of the growth hormone (GH) axis on lipid metabolism has been well studied, sexual dimorphism has not been considered. Furthermore, the effects of the GH axis on intergenerational adipose development are understudied. The present study aimed to evaluate whether adipose-specific Ghr knockout is associated with sex-specific differences in metabolic health of female offspring.

Methods

Ghr^flox/flox (LL) mice were crossed with Adipoq-Cre mice to generate adipose-s

SUBMITTER: Ran L 

PROVIDER: S-EPMC11610217 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature