Oral vancomycin use and incidence of vancomycin-resistant enterococci: time-series analysis.

ABSTRACT:

Background

Vancomycin exposure is a major risk factor for vancomycin-resistant enterococci (VRE) colonisation, but the relationship between oral vancomycin and the risk of VRE colonisation remains poorly understood without ecological evidence. In this study, we investigated the association between oral vancomycin usage and the incidence of hospital-acquired VRE using a time-series analysis.

Methods

This retrospective ecological study analysed monthly data on antibiotic usage and VRE incidence from January 2013 to December 2022 at a 2700-bed hospital in South Korea. Antibiotic usage was measured in days of therapy (DOT) per 1000 patient-days. Hospital-acquired VRE incidence was defined as the number of VRE isolates identified more than 48 h after admission per 1000 patient-da

SUBMITTER: Bae S 

PROVIDER: S-EPMC11610259 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature