A reactive oxygen species-related signature predicts the prognosis and immunosuppressive microenvironment in gliomas.

ABSTRACT:

Objective

Intracellular redox homeostasis is crucial for a series of physiological processes. Reactive oxygen species (ROS) play important roles in redox processes. ROS can maintain cell reproduction and survival at moderate levels while promoting the initiation and progression of tumors at high levels.

Methods

Based on a comprehensive analysis of ROS-related gene expression profiles, we established a gene signature associated with ROS to explore its influence on prognosis and immune microenvironment in gliomas.

Results

The ROS-related gene expression profile dichotomized patients into two groups with different clinicopathological features and prognoses. A 19-gene ROS-related signature was used to robustly predict prognosis in both training and validation datasets. Fu

SUBMITTER: Shan X 

PROVIDER: S-EPMC11610310 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature