Berberine ameliorates dextran sulfate sodium -induced colitis through tuft cells and bitter taste signalling.

ABSTRACT:

Background

Inflammatory bowel disease (IBD), a persistent gastrointestinal disease, is featured with impaired gut immunity. Previous studies have demonstrated that tuft cells can regulate the intestinal type 2 immune response by activating downstream ILC2 and Th2 cells and repair gut barrier upon invasion of parasitic helminths, bacteria, protozoans, and enteritis through different chemo-sensing receptors, such as bitter taste receptors. Berberine is a widely used in the treatment of diarrhea in clinic, however the mechanism underlying this effect is not clear. In this study, we aim to explore the relationship between berberine and tuft cells in dextran sulfate sodium (DSS) -induced colitis.

Results

Our data showed that berberine significantly ameliorated DSS-induced colitis

SUBMITTER: Yang Y 

PROVIDER: S-EPMC11610372 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature