Sorbitol-Based Glass Matrices Enable Dynamic Nuclear Polarization beyond 200 K.

ABSTRACT: In magic angle spinning dynamic nuclear polarization (MAS-DNP) experiments, paramagnetic species are often dispersed in rigid glass-forming matrices such as glycerol/water mixtures, but their modest glass-transition temperature (T_g) restricts the viable temperature range for MAS-DNP. To expand applications of DNP at higher temperatures, new matrices and physical insights are required. Here we demonstrate that sorbitol, T_g ≈ 267 K, advantageously replaces glycerol, T_g ≈ 190 K, to carry out DNP at higher temperature while maintaining an identical ¹³C NMR spectrum footprint and thus minimizing spectral overlap. DNP stops being effective in glycerol/water at ∼180 K, but sorbitol/DMSO gives a significant enhan

SUBMITTER: Scott FJ 

PROVIDER: S-EPMC11610384 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature