Comparative analysis of oral saliva microbiomes and metabolites in Han population at different altitudes.

ABSTRACT:

Objective

This study investigated the differences in oral saliva microbiota composition and metabolic products among Han Chinese populations living at different altitudes, as well as their correlations.

Method

The analysis was conducted using the 16S rRNA gene sequencing method and untargeted metabolomics.

Results

16S gene sequencing results showed significant differences in bacterial diversity and composition between HH (High altitude Han) group and LH (Low altitude Han) group. LEfSe analysis showed that Selenomonas, Leptotrichia, Veillonella, Prevotella relatively abundant are higher in HH group, Haemophilus, Neisseria, Actinobacillus, Aggregatibacter are higher in LH group (p<0.05). Furthermore, as depicted in the phylogenetic tree, there are differences obs

SUBMITTER: Li J 

PROVIDER: S-EPMC11610449 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature