Aspirin resistance in pregnancy is associated with reduced interleukin-2 (IL-2) concentrations in maternal serum: Implications for aspirin prophylaxis for preeclampsia.

ABSTRACT:

Objectives

To evaluate the impact of aspirin resistance on the incidence of preeclampsia and maternal serum biomarker levels in pregnant individuals at high-risk of preeclampsia receiving low dose aspirin (LDA).

Study design

We performed a secondary analysis of a randomized, placebo-controlled trial of LDA (60 mg daily) for preeclampsia prevention in high-risk individuals (N = 524) on pregnancy outcomes and concentrations of PLGF, IL-2, IL-6, thromboxane B2 (TXB₂), sTNF-R1 and sTNF-R2 from maternal serum.

Main outcome measures

LDA-resistant individuals were defined as those having a TXB₂ concentration >10 ng/ml or <75 % reduction in concentration at 24-28 weeks after LDA administration. Comparisons of outcomes were performed using a Fisher's Exac

SUBMITTER: Hernandez F 

PROVIDER: S-EPMC11610477 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature