Xylose utilization promotes <i>Salmonella</i> replication within macrophages and systemic infection in mice.

ABSTRACT: The intracellular pathogen Salmonella can cause systemic diseases via its survival and replication in host macrophages. Xylose is the second most abundant sugar in nature and Salmonella can use xylose as its sole carbon source for growth. However, whether xylose utilization contributes to the pathogenicity and intracellular growth of Salmonella has not yet been determined. In this study, we observed that the xylose concentration in macrophages increased during Salmonella infection. Moreover, there was an increase in expression of Salmonella xylose catabolic genes (xylA and xylB) and the transcriptional regulatory gene of xylose metabolism (xylR) in macrophages, revealing the possibility of using host-accumulated xylose by Salmonell

SUBMITTER: Wang X 

PROVIDER: S-EPMC11610547 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature