Humatch - fast, gene-specific joint humanisation of antibody heavy and light chains.

ABSTRACT: Antibodies are a popular and powerful class of therapeutic due to their ability to exhibit high affinity and specificity to target proteins. However, the majority of antibody therapeutics are not genetically human, with initial therapeutic designs typically obtained from animal models. Humanization of these precursors is essential to reduce immunogenic risks when administered to humans.Here, we present Humatch, a computational tool designed to offer experimental-like joint humanization of heavy and light chains in seconds. Humatch consists of three lightweight Convolutional Neural Networks (CNNs) trained to identify human heavy V-genes, light V-genes, and well-paired antibody sequences with near-perfect accuracy. We show that these CNNs, alongside germline similarity, can be used for fast

SUBMITTER: Chinery L 

PROVIDER: S-EPMC11610552 | biostudies-literature | 2024 Jan-Dec

REPOSITORIES: biostudies-literature