DNA damage repair factor Rad18 controls virulence partially via transcriptional suppression of genes <i>HWP1</i> and <i>ECE1</i> in <i>Candida albicans</i>.

ABSTRACT: DNA damage repair is a crucial cellular mechanism for rectifying DNA lesions arising during growth and development. Among the various repair pathways, postreplication repair (PRR) plays a pivotal role in resolving single-stranded gaps induced by DNA damage. However, the contribution of PRR to virulence remains elusive in the fungal pathogen Candida albicans (C. albicans). In this study, we investigated the role of Rad18, a critical component of PRR, in DNA damage response and virulence in C. albicans. We observed that deletion of RAD18 in C. albicans resulted in heightened sensitivity to DNA damage stress. Through deletion of specific internal domains coupled with spot assay analysis, we show that the internal RING and SAP domains play essential roles in DNA dam

SUBMITTER: Chen R 

PROVIDER: S-EPMC11610567 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature