Unraveling the architecture of major histocompatibility complex class II haplotypes in rhesus macaques.

ABSTRACT: The regions in the genome that encode components of the immune system are often featured by polymorphism, copy number variation, and segmental duplications. There is a need to thoroughly characterize these complex regions to gain insight into the impact of genomic diversity on health and disease. Here we resolve the organization of complete major histocompatibility complex (MHC) class II regions in rhesus macaques by using a long-read sequencing strategy (Oxford Nanopore Technologies) in concert with adaptive sampling. In particular, the expansion and contraction of the primate DRB-region appear to be a dynamic process that involves the rearrangement of different cassettes of paralogous genes. These chromosomal recombination events are propagated by a conserved pseudogene, DRB6</

SUBMITTER: de Groot N 

PROVIDER: S-EPMC11610599 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature