LncRNA EIF3J-DT promotes chemoresistance in oral squamous cell carcinoma.

ABSTRACT:

Objectives

This study aimed to screen oral squamous cell carcinoma (OSCC) diagnostic and prognostic candidates and investigate the potential functions and mechanisms of candidates in the chemoresistance of OSCC cell lines.

Materials and methods

Differential expression profiling of lncRNA was performed in a large cohort of OSCC patients from the Cancer Genome Atlas database to identify OSCC diagnostic and prognostic candidates. Taxol resistance in OSCC cell lines was analyzed using MTT assay. OSCC cell lines transfected with EIF3J-DT pcDNA or siRNA were used to determine its regulatory effects on apoptosis, cell cycle distribution and autophagy using flow cytometry and western blot.

Results

We identified EIF3J-DT as a candidate for OSCC diagnosis and prognosis. The exp

SUBMITTER: Kim SH 

PROVIDER: S-EPMC11610658 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature