Functional expression and regulation of eukaryotic cytochrome P450 enzymes in surrogate microbial cell factories.

ABSTRACT: Cytochrome P450 (CYP) enzymes play crucial roles during the evolution and diversification of ancestral monocellular eukaryotes into multicellular eukaryotic organisms due to their essential functionalities including catalysis of housekeeping biochemical reactions, synthesis of diverse metabolites, detoxification of xenobiotics, and contribution to environmental adaptation. Eukaryotic CYPs with versatile functionalities are undeniably regarded as promising biocatalysts with great potential for biotechnological, pharmaceutical and chemical industry applications. Nevertheless, the modes of action and the challenges associated with these membrane-bound proteins have hampered the effective utilization of eukaryotic CYPs in a broader range. This review is focused on comprehensive and consolidate

SUBMITTER: Durairaj P 

PROVIDER: S-EPMC11610987 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature