Genetic Ancestry-specific Molecular and Survival Differences in Admixed Patients With Breast Cancer.

ABSTRACT:

Objective

We aim to determine whether incremental changes in genetic ancestry percentages influence molecular and clinical outcome characteristics of breast cancer in an admixed population.

Background

Patients with breast cancer are predominantly characterized as "Black" or "White" based on self-identified race/ethnicity or arbitrary genetic ancestry cutoffs. This limits scientific discovery in populations that are admixed or of mixed race/ethnicity as they cannot be classified based on historical race/ethnicity boxes or genetic ancestry cutoffs.

Methods

We used The Cancer Genome Atlas cohort and focused on genetically admixed patients that had less than 90% European, African, Asian, or Native American ancestry.

Results

Genetically admixed patients with breast

SUBMITTER: Telonis AG 

PROVIDER: S-EPMC11611248 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature