Impact of Neighborhood Disadvantage on Tumor Biology and Breast Cancer Survival.

ABSTRACT:

Objective

The aim of this study was to evaluate the association between neighborhood disadvantage and Oncotype DX score, a surrogate for tumor biology, among a national cohort.

Background

Women living in disadvantaged neighborhoods have shorter breast cancer (BC) survival, even after accounting for individual-level, tumor, and treatment characteristics. This suggests unaccounted social and biological mechanisms by which neighborhood disadvantage may impact BC survival.

Methods

This cross-sectional study included stage I and II, ER + /HER2 - BC patients with Oncotype DX score data from the National Cancer Database (NCDB) from 2004 to 2019. Multivariate regression models tested the association of neighborhood-level income on Oncotype DX score controlling for age, race/e

SUBMITTER: Goel N 

PROVIDER: S-EPMC11611249 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature