Adverse cardiovascular events and cardiac imaging findings in patients on immune checkpoint inhibitors.

ABSTRACT:

Background

There is an urgent need to better understand the diverse presentations, risk factors, and outcomes of immune checkpoint inhibitor (ICI)-associated cardiovascular toxicity. There remains a lack of consensus surrounding cardiovascular screening, risk stratification, and clinical decision-making in patients receiving ICIs.

Methods

We conducted a single center retrospective cohort study including 2165 cancer patients treated with ICIs between 2013 and 2020. The primary outcome was adverse cardiovascular events (ACE): a composite of myocardial infarction, coronary artery disease, stroke, peripheral vascular disease, arrhythmias, heart failure, valvular disease, pericardial disease, and myocarditis. Secondary outcomes included all-cause mortality and the individual comp

SUBMITTER: Kwan JM 

PROVIDER: S-EPMC11611253 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature