Dopamine neurons that inform Drosophila olfactory memory have distinct, acute functions driving attraction and aversion.

ABSTRACT: The brain must guide immediate responses to beneficial and harmful stimuli while simultaneously writing memories for future reference. While both immediate actions and reinforcement learning are instructed by dopamine, how dopaminergic systems maintain coherence between these 2 reward functions is unknown. Through optogenetic activation experiments, we showed that the dopamine neurons that inform olfactory memory in Drosophila have a distinct, parallel function driving attraction and aversion (valence). Sensory neurons required for olfactory memory were dispensable to dopaminergic valence. A broadly projecting set of dopaminergic cells had valence that was dependent on dopamine, glutamate, and octopamine. Similarly, a more restricted dopaminergic cluster with attractive valence was reliant

SUBMITTER: Mohammad F 

PROVIDER: S-EPMC11611264 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature