Sheet-on-sheet fixed target data collection devices for serial crystallography at synchrotron and XFEL sources.

ABSTRACT: Serial crystallography (SX) efficiently distributes over many crystals the radiation dose absorbed during diffraction data acquisition, enabling structure determination of samples at ambient temperature. SX relies on the rapid and reliable replacement of X-ray-exposed crystals with fresh crystals at a rate commensurate with the data acquisition rate. 'Solid supports', also known as 'fixed targets' or 'chips', offer one approach. These are microscopically thin solid panes into or onto which crystals are deposited to be individually interrogated by an X-ray beam. Solid supports are generally patterned using photolithography methods to produce a regular array of features that trap single crystals. A simpler and less expensive alternative is to merely sandwich the microcrystals between two unp

SUBMITTER: Doak RB 

PROVIDER: S-EPMC11611291 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature