Validation of Peripheral Neuromodulation Mechanisms of Icariin in Knee Osteoarthritis-Related Chronic Pain.

ABSTRACT: Knee osteoarthritis (KOA) is a chronic degenerative joint disease-causing chronic pain and disability. Neuromodulation of subchondral bone affects KOA-related pain and involves dorsal root ganglion (DRG). Our previous studies have demonstrated efficacy of icariin (ICA) in treating KOA, but neuromodulation mechanisms in peripheral nerves associated with the treatment of chronic pain in KOA remain unclear. This study aimed to investigate peripheral neuromodulation mechanisms of ICA in KOA-related chronic pain: (1) assessing therapeutic effect of ICA in a rat model of KOA-induced chronic pain; (2) investigating changes in pain-related nerve fibres and transient receptor potential vanilloid Subfamily 1 (TRPV1) pathway in subchondral bone following ICA treatment; and (3) exploring expression of

SUBMITTER: Ma D 

PROVIDER: S-EPMC11611524 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature