Mechanism of <i>Valeriana officinalis L.</i> extract improving atherosclerosis by regulating PGC-1α/Sirt3/Epac1 pathway.

ABSTRACT:

Objective

To investigate the protective effect of the of Valeriana officinalis L. extract on mitochondrial injury in AS mice and the underlying mechanism.

Methods

Firstly, Ultra-High performance liquid chromatography-quadrupole time-of-flight mass spectrometer (UPLC / Q-TOF-MS) was proposed to explore the chemical composition of Valeriana officinalis L. extract. ApoE-/- mice were employed for in vivo experiments. The efficacy of Valeriana officinalis L. extract was detected by B-ultrasound, Biochemical, Oil Red O staining, HE staining and Masson staining analysis. The molecular mechanism of Valeriana officinalis L. extract in regulating mitochondrial energy metabolism for the treatment of atherosclerosis was elucidated after Monitoring System of V

SUBMITTER: Yao B 

PROVIDER: S-EPMC11611558 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature