Dipeptide alanine-glutamine ameliorates retinal neurodegeneration in an STZ-induced rat model.

ABSTRACT:

Introduction

Diabetic retinopathy (DR) is a common complication of diabetes. Retinal neuronal degeneration is an early event in DR, indicated by the declined electroretinogram (ERG). Dipeptide alanine-glutamine (Ala-Gln) is widely used as a nutritional supplement in the clinic and has anti-inflammatory effects on the gastrointestinal system. Studies also reported that glutamine has beneficial effects on diabetes. This study aimed to investigate the possible therapeutic effects of Ala-Gln in diabetic retinal neurodegeneration and to delineate its mechanism of action.

Methods

The Streptozotocin (STZ)-induced rat model was used as a DR model. ERG was used to measure the neuronal function of the retina. Western blot analysis was performed to test the expression of proteins. Immu

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC11611560 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature